If you demux audio and video with DVD2AVI, you get
a audio file around 500mb

So now you know the file file need to be around 3900 mb
(subtitles does not take hardly any space)

The tmpgenc wizard will help you calculate the avarge bitrate
if you use constant and 2pass varible.

Hint:
un-lock the DVD-NTSC templete and re-save it with
your prefered specs as my_dvd etc.

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But is't the CQ_VBR the preferd bitrate mode ???????

But how do you calculate the quility setting so you come
within 5% off 4.38GB ????