Couple of questions I would like to have input on.

If I plan to upscale my 1080p master > UHD with VEAI.

1. Should I skip sharpening on the 1080p timeline and only do it afterwards on the UHD upscaled version (if needed)? Or should I apply some sharpening before upscaling? Sharpening is all the way down in my camera as I do this in post as the last step. I wonder what is the best way if you plan to upscale.
2. Can I use Neat Video noise reduction on the 1080p timeline and put this master into an upscaler? Is this destructive?