In general, you can't mix and match x86, x64 in a single script. (There is an exception, mp_pipeline, that enables you to run mixed scripts such as x86 plugins and filters in a x64 avisynth host or vice versa. But it's more of a workaround)
The application you use will determine which avisynth version is initialized. e.g. if you open .avs with vdub2 x86, then avisynth x86 will run. If you open .avs with vdub2 x64, then avisynth x64 will run. If you use ffmpeg x64, it will initialize avisynth x64 to run the script, etc...
The last one is the "official" and newest . It's a packaged version or r2915 MT
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