best VOB to MP4 encoder for commercial use (regardless of the prices)

[altavistasf]

Hi everyone,
I ve been getting excellent answers on this forum. Thanks for everyone for sharing their expert opinion, especially “Baldrick” from Sweden who has a lot of knwoledge in video (not limited to) and has helped me.
Here is my question:
We are launching our eLearning website for doctors. Currently, our videos are in the VOB format and after investigating around, we found that the best (almost lossless) quality that we could get (especially when the “expand video" feature is used) is the MP4.
“Handbreak” Was recommended and because we have a high number of videos to be converted, I wanted to make sure that this is the best available in the market for commerial use, regardless how much they cost.
I would appreciate it if anyone could suggest some of the best (reliability, ease, and speed).
Many thanks